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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2A
All Species:
27.27
Human Site:
Y428
Identified Species:
46.15
UniProt:
Q9BY44
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9BY44
NP_114414.2
585
64990
Y428
F
P
A
K
T
I
T
Y
Q
A
V
P
S
E
V
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001108004
580
64436
Y423
F
P
A
K
T
I
T
Y
Q
A
V
P
S
E
V
Dog
Lupus familis
XP_534306
585
65159
Y428
F
P
V
K
T
I
T
Y
Q
A
V
P
S
D
V
Cat
Felis silvestris
Mouse
Mus musculus
Q8BJW6
581
64385
Y428
F
P
A
K
T
I
K
Y
Q
A
V
P
S
E
V
Rat
Rattus norvegicus
NP_001102809
541
60196
P409
V
A
T
A
Y
R
P
P
A
L
R
N
K
P
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507598
493
54394
L361
Q
A
Y
R
P
P
A
L
R
N
K
P
V
T
G
Chicken
Gallus gallus
Q5ZKC1
586
64485
Y428
F
P
V
K
A
V
K
Y
Q
A
V
P
S
E
L
Frog
Xenopus laevis
Q7ZY11
582
64798
Y430
F
P
A
K
A
I
V
Y
Q
A
V
P
G
D
L
Zebra Danio
Brachydanio rerio
Q4QRJ7
580
64206
Y427
F
P
E
R
A
V
K
Y
Q
A
L
P
S
E
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VNX8
638
70052
K444
F
S
E
P
K
I
T
K
A
K
H
E
G
I
K
Honey Bee
Apis mellifera
XP_625143
577
65273
Y427
F
P
E
K
P
I
S
Y
K
A
V
E
G
I
A
Nematode Worm
Caenorhab. elegans
Q19052
570
64001
T432
K
F
A
I
K
E
L
T
K
T
D
K
M
A
A
Sea Urchin
Strong. purpuratus
XP_001186352
299
33040
K166
V
Y
G
F
M
P
A
K
A
T
L
F
N
L
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P53235
642
71286
E447
N
K
D
E
A
F
F
E
N
H
I
I
N
N
W
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
97.4
96
N.A.
92.8
82.5
N.A.
74.5
84.4
74.8
69.5
N.A.
39
43.9
35.7
29.2
Protein Similarity:
100
N.A.
98.2
98.2
N.A.
95.5
87
N.A.
79.4
91.6
86.5
81.5
N.A.
56.5
61.3
54.8
40
P-Site Identity:
100
N.A.
100
86.6
N.A.
93.3
6.6
N.A.
6.6
66.6
66.6
53.3
N.A.
20
46.6
6.6
0
P-Site Similarity:
100
N.A.
100
93.3
N.A.
93.3
6.6
N.A.
20
80
80
80
N.A.
20
60
13.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
26.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
45.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
15
36
8
29
0
15
0
22
58
0
0
0
8
15
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
0
0
0
0
0
0
0
8
0
0
15
0
% D
% Glu:
0
0
22
8
0
8
0
8
0
0
0
15
0
36
0
% E
% Phe:
65
8
0
8
0
8
8
0
0
0
0
8
0
0
0
% F
% Gly:
0
0
8
0
0
0
0
0
0
0
0
0
22
0
8
% G
% His:
0
0
0
0
0
0
0
0
0
8
8
0
0
0
0
% H
% Ile:
0
0
0
8
0
50
0
0
0
0
8
8
0
15
0
% I
% Lys:
8
8
0
50
15
0
22
15
15
8
8
8
8
0
15
% K
% Leu:
0
0
0
0
0
0
8
8
0
8
15
0
0
8
22
% L
% Met:
0
0
0
0
8
0
0
0
0
0
0
0
8
0
0
% M
% Asn:
8
0
0
0
0
0
0
0
8
8
0
8
15
8
0
% N
% Pro:
0
58
0
8
15
15
8
8
0
0
0
58
0
8
0
% P
% Gln:
8
0
0
0
0
0
0
0
50
0
0
0
0
0
0
% Q
% Arg:
0
0
0
15
0
8
0
0
8
0
8
0
0
0
0
% R
% Ser:
0
8
0
0
0
0
8
0
0
0
0
0
43
0
0
% S
% Thr:
0
0
8
0
29
0
29
8
0
15
0
0
0
8
0
% T
% Val:
15
0
15
0
0
15
8
0
0
0
50
0
8
0
36
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% W
% Tyr:
0
8
8
0
8
0
0
58
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _